What's New

Health Canada Approves Orkambi

As many of you may be aware, Health Canada granted approval to the new drug, Orkambi, in late January this year. In anticipation of the interest this is likely to generate among CF patients and their friends and family members, we have prepared a brief FAQ about Orkambi which you can access here. If you have any questions about this medication that are not addressed in the FAQ, please contact the clinic.

Aztreonam Lysine in CF (AZLI)

The purpose of this study is to observe the effects of aztreonam lysine for inhalation (AZLI, trade name Cayston) on Pseudomonas aeruginosa levels in sputum. We are enrolling patients who take Cayston as part of their usual medication regimen. Sputum is to be collected every two weeks during both the ON and OFF cycles of Cayston, over a span of 58 days. Enrollment is open for this study.

For more information, please contact Eri Flores at (604) 682-2344 ext. 63721 or eflores@providencehealth.bc.ca.

VX-661-108: (Vertex 661-108)

This is a phase 3 study of participants with a specific cystic fibrosis mutation (referred to as a residual function mutation) in combination with the F508del-CFTR mutation to determine the safety and efficacy of an investigational drug (VX-661) in combination with ivacaftor. Participants will be randomized to one of six treatment regimens in which they will receive the study drug/placebo for 8 weeks then following an 8-week washout period, they will receive a different drug/placebo for another 8 weeks.

VX-661-106: (Vertex 661-106)

This is a phase 3, placebo-controlled study to evaluate the efficacy and safety of treatment with VX-661 in combination with ivacaftor in subjects homozygous for the F508del-CFTR mutation. Our site is currently recruiting for this study and the planned study duration is 32 weeks.

For more information, please contact Eri Flores at (604) 682-2344 ext. 63721 or eflores@providencehealth.bc.ca

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Posted with permission.  ©Peter Battistoni/Vancouver Sun

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The Adult Cystic Fibrosis Clinic at St. Paul's Hospital is launching its new website!